Association between ischemic stroke, hemorrhagic stroke, dementia, and rs201118034 among general Taiwanese population.

ABSTRACT:

Introduction

We investigated the association between the NOTCH3 rs201118034 variant and the risk of ischemic stroke, hemorrhagic stroke, and dementia within a Taiwanese population.

Methods

Data from 114,233 individuals enrolled in the Taiwan Biobank were analyzed, integrating clinical diagnoses from the National Health Insurance Research Database and genetic information. Participants were aged 30-70 years and had no history of cancer. Diagnoses were categorized using the International Classification of Diseases, Ninth and Tenth Revisions (ICD-9/ICD-10) codes.

Results

The rs201118034 AG+AA genotype significantly increased the risk of ischemic stroke (odds ratio [OR]: 1.50, 95% confidence interval [CI]: 1.21-1.85, p < 0.001) and hemorrhagic stroke (OR: 2.21, 95% CI: 1.4

SUBMITTER: Liaw YC 

PROVIDER: S-EPMC12611863 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature