Early responses of primary human and bovine monocytes, monocytic THP-1 cells and THP-1 cell-derived macrophages to vital <i>Toxoplasma gondii</i> tachyzoites.

ABSTRACT:

Introduction

Different innate immune cell types are known to release extracellular traps (ETs) in response to invasive pathogens, including parasites. These ETs function to trap, immobilize, and eventually kill pathogens. In line with this, monocytes and macrophages have been shown to release ETs, known as monocyte/macrophage extracellular traps (METs). Toxoplasma gondii (T. gondii) is an apicomplexan zoonotic parasite that infects humans and homeothermic animals. While most studies have focused on prolonged exposure of immune cells to T. gondii, this study characterized the early innate immune reaction of mononuclear phagocytes to vital T. gondii tachyzoites.

Methods

Primary human and bovine monocytes, monocytic THP-1 cells, and THP-1 cell-derive

SUBMITTER: Hanke D 

PROVIDER: S-EPMC12611918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature