Ketone ester supplementation protects from experimental colitis via improved goblet cell differentiation and function.

ABSTRACT:

Purpose

A ketogenic diet (KD), high in fat and low in carbohydrates, induces ketosis characterized by elevated circulating ketone bodies. While both KD and ketone bodies have demonstrated therapeutic potential in various pathophysiological conditions, their effect on inflammatory bowel diseases remains controversial. This study aimed to investigate the impact of a KD and ketone ester (KE), an ingestible form of ketone bodies, on intestinal inflammation.

Methods

Acute dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced murine colitis models were used to evaluate and compare the effects of KD feeding and KE supplementation on intestinal inflammation, the mucus barrier and gut microbiota composition.

Results

KD feeding did not significant

SUBMITTER: Rohwer N 

PROVIDER: S-EPMC12611996 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature