Postoperative outcome and clinical management of tumor-induced osteomalacia: a single-center retrospective cohort study on 117 patients.

ABSTRACT: We reported a single-center retrospective cohort study on 117 patients of Tumor-induced osteomalacia (TIO) to summarize our experience with TIO over the past decade. The clinical characteristics, diagnosis, treatment and postoperative outcomes were analyzed. Together, our data demonstrate the characteristics and prognosis of TIO and unveil a possible TIO management process.

Introduction

TIO is a rare paraneoplastic syndrome that ultimately results in debilitating musculoskeletal deficits and regressive activity obstacles due to hypophosphatemia. The diagnosis and treatment of TIO are challenging owing to nonspecific symptoms, occult tumors and the lack of awareness. We aimed to summarize our experience with TIO over the past decade and to optimize its clinical management.

Methods

SUBMITTER: Shan C 

PROVIDER: S-EPMC12612011 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature