Association between Paleolithic diet fraction and systemic low-grade chronic inflammation in the Malmo diet and cancer study cohort.

ABSTRACT:

Purpose

The Paleolithic Diet Fraction (PDF) estimates the proportion of absolute dietary intake derived from food groups included in the Paleolithic diet. In the Malmö Diet and Cancer Study (MDCS), higher PDF and lower systemic low-grade chronic inflammation (SLGCI) have been associated with lower cardiometabolic morbidity and mortality. We examined associations between PDF and SLGCI in the MDCS.

Methods

The study population (n = 23,250; 63% women; ages 44-74 years) excluded participants with prior coronary events, diabetes, stroke, high-grade inflammation, or missing baseline covariate data. PDF was calculated from baseline dietary data collected via food frequency questionnaires, seven-day food records, and interviews. Biomarkers of SLGCI included total leukocyte count (TL

SUBMITTER: Carrera-Bastos P 

PROVIDER: S-EPMC12612027 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature