Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats.

ABSTRACT: Drug-associated stimuli (cues) can usurp potent control of behavior in individuals with substance use disorders; and these effects are often attributed to altered dopamine transmission. However, there is much debate over the way in which dopamine signaling changes over the course of chronic drug use. Here, we carried out longitudinal recording and manipulation of cue-evoked dopamine release in the core of the nucleus accumbens across phases of substance use in male rats. We show that, in a subset of individuals that exhibit increased cue reactivity and escalated drug consumption, this signaling undergoes diametrically opposed changes in amplitude, determined by the context in which the cue was presented. Dopamine evoked by non-contingent cue presentation (independent of the animal's action

SUBMITTER: Burgeno LM 

PROVIDER: S-EPMC12612060 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature