Circular RNA circNRIP1 promotes glioma progression by regulating the miR-106a-5p/GPR133 pathway.

ABSTRACT: Glioma is one of the most common and aggressive types of brain tumors, characterized by generally low survival rates. Circular RNAs (circRNAs) have been identified as key players in the development of glioma. Our study aims to investigate the effect of circNRIP1 on glioma progression and elucidate the underlying mechanisms involved. The mRNA expression of circNRIP1, miR-106a-5p, and GPR133 was determined using qRT-PCR. The protein expression of N-cadherin, E-cadherin, fibronectin, vimentin, and GPR133 in glioma cells and tissues was measured through Western blotting and IHC assays. Cell counting kit-8 (CCK-8), wound healing, and transwell assays were used to determine cell proliferation, migration, and invasion, respectively. The dual-luciferase reporter assay was utilized to elucidate the

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12612068 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature