HPCAL1 as a novel prognostic biomarker in acute myeloid leukemia and its correlation with immune infiltrates.

ABSTRACT: Acute myeloid leukemia (AML), a heterogeneous malignancy with complex molecular mechanisms, urgently requires improved prognostic biomarkers and therapeutic targets. This study investigated Hippocalcin-like 1（HPCAL1）, a calcium-binding protein with dual functionality dependent on cancer type, as a potential prognostic marker and investigated its interaction with the tumor immune microenvironment in AML. Through analyses of multiple independent cohorts (GSE13159, GSE34184, GSE24395 and institutional data), we revealed that significant HPCAL1 overexpression in AML samples was correlated with poor survival outcomes. ESTIMATE analysis revealed increased immune activity in the HPCAL1-high group, which was supported by differential expression profiling, which identified 617 genes enriched in inf

SUBMITTER: Cheng L 

PROVIDER: S-EPMC12612170 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature