Pan-cancer landscape of cellular senescence heterogeneity reveals associations with prognosis and therapy response.

ABSTRACT: Cellular senescence (CS) plays an important role in cancer development and treatment. However, the heterogeneity of CS among different types of cancer and its impacts on patient prognosis and therapy response remain to be fully elucidated. This study performed a comprehensive pan-cancer analysis on the CS landscape of 33 cancer types and 29 normal tissues. The molecular subgroups of CS were identified based on the expression of CS-related genes. Multi-platform data including prognosis, microbiota, immune microenvironment, multi-omics, and drug sensitivity were used to investigate the associations with the CS subgroups. Additionally, 12 single-cell datasets and 19 immunotherapy cohorts were collected to evaluate the CS subgroups. We characterized five pan-cancer CS subgroups with distinct b

SUBMITTER: Chen L 

PROVIDER: S-EPMC12612222 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature