Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity.

ABSTRACT: Metastatic solid tumors (e.g., ovary, pancreas, liver, lung, and brain) contribute to a high mortality rate in cancer patients with few therapeutically effective anticancer drugs available for their treatment, highlighting the need to develop agents that target solid tumors. Natural products (NPs) derived from cyanobacteria possess potent anticancer activity, yet most are hard to synthesize and modify to improve therapeutic efficacy. Here, we have efficiently synthesized a simplified analog of the marine NP majusculamide D, majusculamide o (maj-o, 1), that has remarkable potency and selective cytotoxicity towards various metastatic cancer cells. We found that maj-o (1) treatment presents potent cytotoxicity in various cancer cell lines of the ovary (OVCAR3), pancreas (PANC1), brain (U251N)

SUBMITTER: Wahl NA 

PROVIDER: S-EPMC12612262 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature