F8 Variants and Inhibitor Development in a Multiethnic Cohort of Nonsevere Haemophilia A.

ABSTRACT:

Background

Neutralising antibodies (inhibitors) against factor VIII can result in severe bleeding in persons with nonsevere haemophilia A (NSHA). The INSIGHT study of 1112 persons with NSHA in a predominantly White population identified 19 different F8 missense variants that were associated with inhibitor development.

Objective

To describe the F8 variants and inhibitor development in persons with NSHA in a multiethnic cohort using the My Life, Our Future (MLOF) Research Repository and the American Thrombosis and Hemostasis Network dataset (ATHNdataset).

Methods

The MLOF Research Repository and ATHNdataset were queried for demographic, clinical and genotyping data.

Results

A total of 1805 persons with NSHA with at least one reportable F8 variant and known inhibi

SUBMITTER: Lim MY 

PROVIDER: S-EPMC12612360 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature