The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial.

ABSTRACT:

Background

Collaborative care models (CoCM) improve both depression and cardiometabolic outcomes, but the mechanisms driving these effects remain unclear.

Objective

To determine whether changes in depressive symptoms, positive health behaviors (PHBs), body mass index (BMI), and waist circumference mediate the effect of an adapted CoCM on glycemic control among adults with cardiometabolic risk in India.

Design

Longitudinal structural equation modeling of data from the INtegrating DEPrEssioN and Diabetes TreatmENT (INDEPENDENT) Randomized Control Trial.

Participants

Adults in India with type 2 diabetes or elevated cardiometabolic risk factors and clinically significant depressive symptoms.

Interventions

An adapted CoCM integrating behavioral activation (BA

SUBMITTER: Cooper ZW 

PROVIDER: S-EPMC12612419 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature