Development of the rationale of a personalized cancer vaccine based on the in situ vaccine effect of radiotherapy: a mechanistic study of the POLARSTAR trial.

ABSTRACT:

Purpose

Radiotherapy induces multiple forms of tumor cell death, including immunogenic cell death (ICD) like GSDME-mediated pyroptosis and MLKL-mediated necroptosis; and ICD has been increasingly accepted as a crucial element leading to enhanced anti-tumor adaptive immunity. We aim to clarify whether a vaccine-like effect is intrinsic for radiation-induced tumor cell death, and to explore potential applications.

Methods

A randomized controlled trial was performed to validate the synergism between clinical radiotherapy and PD1 blockade in patients with resectable rectal cancer. Colorectal cancer cell lines and patient-derived organoids were used to study the impact of ionizing radiation on tumor cells. Syngeneic mouse tumor models were used to study the microenvironment modul

SUBMITTER: Pang K 

PROVIDER: S-EPMC12612425 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature