Generating CAR-macrophages to target endothelin B receptor-positive tumors.

ABSTRACT: The endothelin axis is highly involved and overexpressed in many tumors, making it an interesting therapeutic target. However, except for strategies based on small molecule antagonists, this axis is poorly targeted by immunotherapy approaches. Although cell-based therapies, in particular CAR-T cells, have produced impressive results in treating hematological tumors, they remain challenging for solid tumors. CAR-macrophages represent a promising alternative, but only a few therapeutic targets have been evaluated thus far. Having developed antibodies targeting ET1R, our laboratory proposes this axis as a target for CAR-macrophages development. This study investigated the efficacy of CAR-macrophages directed against the endothelin B receptor (ET_B), expressed by melanoma cells devel

SUBMITTER: Lherminier C 

PROVIDER: S-EPMC12612446 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature