The Additional Prognostic Value of Serial Biomarker Measurements for Extubation Failure Among Patients With COVID-19 Acute Respiratory Distress Syndrome.

ABSTRACT:

Background

Extubation failure is associated with adverse outcomes in critically ill patients. While single biomarker measurements can aid prediction, repeated biomarker measurements can help to timely recognize underlying diseases.

Objectives

The aim of this study was to investigate the temporal evolution of cardiac (N-terminal pro-B-type natriuretic peptide [NT-proBNP], high-sensitivity troponin T [Hs-TnT]) and inflammatory biomarkers (interleukin-6 [IL-6] and procalcitonin [PCT]) prior to extubation and determine their additional prognostic value.

Design

Retrospective cohort study.

Methods

Patients with COVID-19 extubated after mechanical ventilation were included. Daily biomarker levels were collected up to 3 days before extubation. The primary endpoint was

SUBMITTER: Groenland CNL 

PROVIDER: S-EPMC12612537 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature