Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein-Barr Virus and Multiple Sclerosis.

ABSTRACT:

Background

We conducted a retrospective in silico analysis of routine laboratory data (RISAROLDA) to study the association of Epstein-Barr virus (EBV) and multiple sclerosis (MS).

Methods

Patients with MS and 10 different inflammatory/neoplastic diseases were identified by ICD10 codes. Results of routine laboratory testing for antibodies to EBV, measles, mumps, rubella, herpes simplex virus, varicella zoster virus and cytomegalovirus were extracted using a digital tool.

Results

Among 10,669 patients with MS and 42,222 controls, EBV serologies were available from 492 (4.6%) patients with MS and 1918 (4.5%) controls. While all but three patients with an ICD10 diagnosis of MS were EBV seropositive, closer inspection of the three EBV seronegative patients revealed they we

SUBMITTER: Rodomonti M 

PROVIDER: S-EPMC12612553 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature