White and gray brain matter activity during pain in fibromyaliga patients and healthy controls.

ABSTRACT: Functional neuroimaging studies have shown that a set of cortical brain regions is typically engaged during noxious stimulation and pain perception in humans. Other studies have focused on cortical brain activation patterns in patients suffering from chronic pain conditions such as fibromyalgia. Recent work has shown that functional MRI signals are also present in white matter. In this study, we present an analysis of white and grey matter functional MRI activation during a block-designed pain stimulus task in cohorts of fibromyalgia patients and healthy controls. Task data and resting-state functional MRI data were collected from female fibromyalgia patients (N = 54) and controls (N = 56). Pain-stimulation task-based functional MRI included noxious pressure of the left shin

SUBMITTER: Fransson P 

PROVIDER: S-EPMC12612582 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature