Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study.

ABSTRACT: Thalamic subregions are commonly, but variably, affected by different forms of frontotemporal dementia. We aimed to better characterize thalamic subregional involvement in genetic frontotemporal dementia with a recently published thalamus segmentation tool that utilizes structural and diffusion MRI, offering additional assessment of mean diffusivity and a more fine-grained analysis of the pulvinar specifically compared to previous studies. Using this tool, we performed thalamus segmentations in MRI scans from C9orf72, GRN and MAPT mutation carriers and mutation non-carriers with suitable 3-Tesla MRI cross-sectional data from the GENetic Frontotemporal dementia Initiative. Mutation carriers were divided according to their genetic group and Clinical Dementia Rating® Deme

SUBMITTER: Soskic S 

PROVIDER: S-EPMC12612583 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature