Stereotactic Functional Neurosurgery Combining Sedation and Awake Procedures Using Remimazolam Besylate and Flumazenil: A Technical Note.

ABSTRACT: Current anesthesia methods for stereotactic functional neurosurgery face significant limitations. Local anesthesia and mild sedation often lead to patient discomfort, while general anesthesia precludes real-time neurological assessments critical for optimizing therapeutic outcomes. This technical note introduces a novel sedation protocol using remimazolam besylate combined with flumazenil in 30 patients with movement disorders undergoing stereotactic functional neurosurgery between November 2022 and March 2024. Remimazolam besylate was administered intravenously for sedation while maintaining spontaneous respiration, with doses adjusted based on patient response and bispectral index values. Sedation was reversed using flumazenil, allowing patients to awaken for neurological assessments; th

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC12612584 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature