Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis.

ABSTRACT:

Background

Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast-twitch muscle fibres are characterized by their rapid contraction kinetics, high-force generation and a distinct gene expression profile compared to slow-twitch fibres. These fibres have a predominant expression of fast skeletal myosin binding protein-C (fMyBP-C). The role of fMyBP-C in skeletal muscle disease and aging remains poorly understood. To address this, our study employs mouse models with fMyBP-C ablation to investigate its significance in skeletal muscle physiology.

Methods

Skeletal muscle samples from wild-type, db/db, MDX and ECC injury model (2-7 months) were analysed to determine the fMyBP-C levels. Next, male Mybpc2 knockout (C2^-/-) mice, both young (3-5 months

SUBMITTER: Baby A 

PROVIDER: S-EPMC12612635 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature