PASS2: update of database of structure-based sequence alignments.

ABSTRACT: Protein sequence alignments are evolutionary models and offer as starting points for the recognition of additional members of a homologous family and design of experiments. However, the accuracy of sequence alignments is obscured at the superfamily level due to distant relationships. Where structures of proteins are available, distantly related proteins can be aligned, guided by structural features. The Protein Alignment Organized as Structural Superfamilies (PASS2) database offers such structure-based sequence alignments for protein domains classified within superfamilies, as per the Structural Classification of Proteins extended (SCOPe) framework. The present update of PASS2 (PASS2.8) corresponds to the latest SCOPe release (version 2.08). This release comprises data for 26 690 protein d

SUBMITTER: Menon R 

PROVIDER: S-EPMC12612674 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature