Analysis of the oral microbiome composition of healthy individuals and the <i>in vitro</i> antibacterial activity of platelet-rich fibrin from these individuals against oral pathogenic bacteria.

ABSTRACT: Platelet-rich fibrin (PRF) is a platelet concentrate widely applied in various medical fields and is considered a valuable adjunct in tissue regeneration during surgical procedures. However, infections caused by biofilm-forming bacteria at surgical sites, combined with increasing antibiotic resistance, present a major clinical concern. Current research is focused on identifying alternative therapeutic strategies to improve infection control and promote wound healing. This study aimed to characterize the oral microbiome of healthy individuals and evaluate the in vitro antimicrobial properties of two PRF formulations. The antibacterial activity, along with its temporal dynamics at different initial bacterial concentrations, was assessed against Gram-negative bacteria (Escherichia c

SUBMITTER: Popowski W 

PROVIDER: S-EPMC12612686 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature