Oral microbiome dysbiosis is associated with chronic respiratory diseases: evidence from a population-based study and a hospital cohort.

ABSTRACT:

Background

The oral microbiome has been increasingly recognized for its role in systemic health through the oral-lung axis. However, population-level evidence linking oral microbial diversity and composition with chronic respiratory diseases (CRD) remains limited.

Methods

We analyzed data from 4,384 adults in the 2009-2012 National Health and Nutrition Examination Survey (NHANES), defining CRD by self-reported chronic obstructive pulmonary disease (COPD), asthma, emphysema, or chronic bronchitis. Oral rinse samples underwent 16S ribosomal RNA (16S rRNA) V1-V3 sequencing. Alpha diversity, including observed amplicon sequence variants (ASVs), Faith's phylogenetic diversity (Faith's PD), Shannon-Weiner index, and Simpson index, and beta diversity, including Bray-Curtis, weighte

SUBMITTER: Jia B 

PROVIDER: S-EPMC12612837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature