Oxadiargyl analogs as potent inhibitors of Toxoplasma gondii protoporphyrinogen oxidase.

ABSTRACT: Toxoplasma gondii infects approximately one-third of the human population, posing a severe and potentially fatal risk to individuals with compromised immune systems. Our previous studies demonstrated that modifying the arene in the herbicidal protoporphyrinogen oxidase (PPO) inhibitor, oxadiazon, yields analogs that potently inhibit T. gondii PPO, a key enzyme in the heme biosynthesis pathway. In this study, we further investigated the structure-activity relationship of oxadiazon analogs by introducing aliphatic chains with varying functionalities, resulting in 23 new derivatives. Some of these compounds exhibited significant intracellular inhibition of wild-type T. gondii, with IC₅₀ values ranging from 2 to 3 μM. Biochemical analysis confirmed that their mo

SUBMITTER: Kwain S 

PROVIDER: S-EPMC12612854 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature