Comparison of Benefit-to-Burden Ratios for Stool-Based Colorectal Cancer Screening Tests in the U.S.: A Decision Analytical Modeling Approach.

ABSTRACT:

Introduction

The U.S. Preventive Services Task Force recommends average-risk colorectal cancer screening beginning at age 45 years with the multitarget stool DNA test at 1-3-year intervals or annual fecal immunochemical tests. In this decision analytical model study, the validated Colorectal Cancer Adenoma Incidence and Mortality model incorporated updated aggregate test performance data to estimate the benefit-to-burden ratio of stool-based screening tests across recommended intervals and age ranges and identify the efficient strategies.

Methods

Screening strategies of multitarget stool DNA or fecal immunochemical tests at 1-3-year intervals over various age ranges were evaluated for average-risk individuals in the U.S. Performance inputs for an updated marker panel (next-g

SUBMITTER: Kisiel JB 

PROVIDER: S-EPMC12613005 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature