Identification of an in-frame insertion in ACKR1 in five individuals from Agri community, India.

ABSTRACT:

Introduction

Atypical chemokine receptor 1 (ACKR1) which carries the Duffy antigens, is not just a blood group antigen but serves many more functions. It is a receptor for various pro-inflammatory and inflammatory chemokines and for Plasmodium vivax. Genetic variations in ACKR1 are the basis for Duffy blood group antigens.

Methods

Routine serological Fy^a/Fy^b typing and ACKR1 genotyping by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism was employed in a population study that included 331 samples from the Agri community.

Results

Weak Fy^b expression was detected by serological findings in five unrelated samples, which prompted further investigation by molecular means. By Polymerase Chain Reaction an aberrant pattern wa

SUBMITTER: Roshan S 

PROVIDER: S-EPMC12613020 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature