The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.

ABSTRACT:

Introduction

The Neighborhoods Study (TNS) is a novel investigation of adverse social exposome and brain health leveraging 22 Alzheimer's Disease Research Centers (ADRCs). TNS aims to understand if the adverse social exposures increase Alzheimer's disease and related dementias (ADRD) risk.

Methods

TNS uses innovative methods to determine lifetime addresses of living (n = ≈ 3116) and brain bank cohorts (n = ≈ 8637). Addresses are linked to time-concordant adverse social exposome using the Area Deprivation Index (ADI) and summarized over time. Brain health measures are provided by the National Alzheimer's Coordinating Center.

Results

We highlight a general overview and methodology of TNS. Data collection is ongoing; however, preliminary findings indicate that the advers

SUBMITTER: George GC 

PROVIDER: S-EPMC12613078 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature