Immune Modulation by Personalized vs Standard Prehabilitation Before Major Surgery: A Randomized Clinical Trial.

ABSTRACT:

Importance

Prehabilitation programs are increasingly recognized for their potential to improve surgical outcomes. However, their efficacy remains debated, largely due to a lack of pathophysiologically driven implementation and limited personalization.

Objective

To determine the impact of personalized vs standard prehabilitation on preoperative physical, cognitive, and immune function and postoperative outcomes.

Design, setting, and participants

In this prospective, single-blinded, randomized interventional trial conducted from June 2020 to September 2022 in a single academic medical center, 58 patients undergoing major elective surgery were randomized to standard (n = 30) or personalized prehabilitation (n = 28) using block randomization. Those with contraindication t

SUBMITTER: Cambriel A 

PROVIDER: S-EPMC12613092 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature