Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress: A Randomized Clinical Trial.

ABSTRACT:

Importance

Close social relationships are linked to improved individual health and even longevity. These effects are hypothesized to be mediated through improved neuroendocrine and immune functioning, particularly in individuals who engage in positive and affectionate interactions. However, systematic data examining these factors in humans are currently lacking.

Objective

To investigate the interacting effects of repeated intranasal oxytocin administration, a behavioral microintervention, and daily physical intimacy on neuroendocrine stress responses and dermatological wound healing.

Design, setting, and participants

This randomized clinical trial was a double-blind, randomized, placebo-controlled study whereby participants completed 3 laboratory visits and a 5-day ec

SUBMITTER: Schneider E 

PROVIDER: S-EPMC12613093 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature