Altered GABAergic Homeostasis in the Striatum of Dopamine Transporter Knockout Rats.

ABSTRACT:

Background

It is now widely established that dopamine, despite its nature as a slowacting biogenic monoamine, modulates fast neurotransmitters such as GABA. However, the mechanism through which this occurs still needs to be fully elucidated. The dopamine transporter (DAT) is the primary regulator of dopamine homeostasis, controlling extracellular levels of dopamine as well as its storage in vesicles.

Methods

Here, we took advantage of the availability of dopamine transporter knockout (DAT^-/-) rats, which provide a unique opportunity to investigate the response of the GABAergic system under hyperactivity of the dopaminergic system, a condition found in different disorders of the Central Nervous System. The expression levels of GABAergic markers have been evaluated

SUBMITTER: Targa G 

PROVIDER: S-EPMC12613098 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature