Quantifying motor-cognitive reserve using a novel multi-modal stress test.

ABSTRACT: Reserve is a physiological capacity used under demanding situations. The concept was developed to account for the discrepancy between pathology and clinical manifestation. In neuroscience, motor, brain and cognitive reserves are abstract measures, conceptually defined yet elusive to quantify. Reserve is indirectly assessed using proxies such as years of education and brain volume, limiting its utility. Moreover, the dichotomy in definitions of cognitive and motor reserves is artificial, as daily function requires an intricate network of connections between these domains. Here, we assessed the validity of a newly developed graded motor cognitive 'stress test' to quantify the combined motor and cognitive reserve (MCR). The study included 144 participants (ages between 18 and 85, 50% w

SUBMITTER: Kozlovski T 

PROVIDER: S-EPMC12613160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature