Maternal hypertension and telomere length are associated with weight for age Z score change from birth to 6 months of age in a predominantly Latinx cohort.

ABSTRACT:

Background

Weight gain in the first six months of life is a predictor of future obesity with rapid infant weight gain (RIWG) (change > 0.67 SD in weight for age Z score from birth to 6 months of age), a strong predictor for obesity at age 5.

Methods

We recruited a multi-racial birth cohort of primarily Latinx mothers and newborns at two San Francisco hospitals. Dried blood spots were taken from infants for leukocyte telomere length (LTL) analysis. Multivariable models were used to evaluate risk factors for RIWG, weight for age Z score (WAZ) change and WAZ at 6 months including gestational and/or pre-existing hypertension and LTL. Separate models were run for term infants ( > = 37 weeks).

Results

Slightly over one third of infants (35.76%) had RIWG (total N = 330). Hyp

SUBMITTER: Wojcicki JM 

PROVIDER: S-EPMC12613348 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature