Upregulation of metallophore-related genes of community-acquired methicillin-resistant Staphylococcus aureus enhances pathogenicity in BALB/c mice.

ABSTRACT:

Background

Our previous study revealed that ST59-t437-SCCmecIVa methicillin-resistant Staphylococcus aureus (MRSA) has strong pathogenicity and can cause damage to host tissue and cell death. However, the interaction between the pathogen and the host during the infection process remains unclear. This study developed an infection interaction model of highly virulent ST59-t437-SCCmecIVa in MRSA and BALB/c mice.

Results

The results revealed that the lungs were among the main organs involved, with high bacterial loads in the lung tissue of infected mice. WGCNA and Cytoscape analysis revealed that the metallophore-related genes of MRSA associated with the virulence factors of the strain formed an interaction network. Prokaryotic strand-specific RNA-seq analyses in vivo and in vit

SUBMITTER: Liao F 

PROVIDER: S-EPMC12613392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature