Comparative efficacy of new wake-promoting agents for narcolepsy-a network meta-analysis.

ABSTRACT:

Background

As a rare sleep disorder, narcolepsy is treated with various therapeutic options. This article systematically analyzes the efficacy and safety of novel approved wake-promoting drugs.

Methods

Randomized controlled trials (RCTs) for patients with narcolepsy and treated with approved interventions were searched. Outcome measures included Epworth sleepiness scale (ESS) score, mean latency in the maintenance of wakefulness test (MWT), cataplexy frequency, number of subjects with ESS scores < 10, standard deviation of lane position (SDLP) score, and adverse events (including anxiety, dizziness). This paper was registered in INPLASY (INPLASY2024120052).

Results

The final analysis included 13 RCTs with four drugs involved: modafinil/armodafinil, sodium oxybate (SXB

SUBMITTER: Yan Z 

PROVIDER: S-EPMC12613485 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature