IPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3.

ABSTRACT:

Background

Natural killer (NK) cells, essential components of the innate immune system, undergo subtype changes with aging that diminish their cytotoxic and tumor surveillance functions. Recent reports indicate that small extracellular vesicles (sEVs) derived from stem cells could ameliorate age-related diseases, while their effects on NK cell senescence remain unexplored.

Methods

We administered induced pluripotent stem cell(iPSC) derived sEVs via tail vein injection for 6 months to naturally aged mouse models. Then we detected a senescent phenotype of splenic NK cells based on a series recognized markers in aged mice. To further investigate the impact of iPSC-sEVs mediated rejuvenation on NK cell function in vivo, purified splenic NK cells from iPSC-sEVs or vehicle-treated

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12613503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature