Non-Lethal heat shock induces COMMD gene activation and enhances pathogen defense in Procambarus clarkii.

ABSTRACT:

Background

The COMMD (copper metabolism MURR1 domain-containing) protein family, characterized by a conserved COMM domain, plays crucial roles in metal ion transport and NF-κB signaling regulation in vertebrates. However, its functional roles in invertebrates, particularly crustaceans, remain poorly understood. This study aimed to identify and characterize COMMD family genes in red swamp crayfish (Procambarus clarkii) and to investigate their involvement in immune responses under environmental stress.

Results

Seven COMMD genes (COMMD2, COMMD3, COMMD4, COMMD5, COMMD7, COMMD8, and COMMD10) were identified and analyzed in P. clarkii. These genes exhibited distinct genomic structures and tissue-specific expression profiles. COMMD2, COMMD3, COMMD8, and COMMD10 were predominantly

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12613529 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature