The lung cancer-associated blood biomarker hPG₈₀ exhibits a reversible increase in response to smoking in asymptomatic individuals.

ABSTRACT: The blood biomarker hPG₈₀ is linked to multiple solid tumors, including lung cancer. This study examined blood hPG₈₀ levels of asymptomatic individuals and patients with non-small cell lung cancer (NSCLC), categorized by their smoking and chronic obstructive pulmonary disease (COPD) status. Plasma hPG₈₀ levels were measured across five cohorts of patients, including 396 NSCLC patients, 200 NSCLC cancer-free COPD patients, 369 asymptomatic never smokers, 278 asymptomatic current smokers, and 235 asymptomatic former smokers. Receiver operating characteristic (ROC) curves assessed diagnostic accuracy. In asymptomatic current smokers, hPG₈₀ levels were significantly higher (6.70 pM (IQR: 5.13-11.29)) than those in gender- and age-matched never smoker

SUBMITTER: Vire B 

PROVIDER: S-EPMC12613591 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature