Impact of oral anaerobic bacteria on the tumor immune microenvironment and prognosis of oral cancer.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) accounts for > 90% of oral cancers and has a poor prognosis. The microbiota affects the tumor microenvironment and tumor immune responses; however, the relationship between specific bacterial compositions and tumor-infiltrating immune cells in OSCC remains unclear.

Methods

The microbial diversity and compositions of tumor, normal mucosa, and stool samples from 42 OSCC patients were examined using 16S rDNA sequencing. Bacterial sampling was performed preoperatively by swabbing the tumor surface and normal mucosa and scraping a deep portion of the tumor. Differences in bacterial compositions between samples were examined using a linear discriminant analysis effect size analysis. To investigate the functional states of T cells, tum

SUBMITTER: Kashima K 

PROVIDER: S-EPMC12613598 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature