A single-cell multi-omics framework identifies immune cell drivers of migraine and repurposable therapeutics.

ABSTRACT:

Background

Migraine, a complex neurovascular disorder, is closely associated with neuroinflammation and immune dysregulation. However, the high heterogeneity of immune cell populations means that the specific cellular immune mechanisms driving migraine susceptibility remain unclear.

Methods

We integrated single-cell expression quantitative trait locus (sc-eQTL) data by applying single-cell Mendelian randomization (Mendelian randomization applied at single-cell resolution, scMR) and colocalization analyses to systematically explore immune-mediated regulatory mechanisms underlying migraine and to identify potential therapeutic targets.

Results

We assessed the causal effects of 9,117 unique sc-eQTLs on migraine across 14 immune cell types. Four genes (PRDM11, VIM, FGFRL1

SUBMITTER: Li DP 

PROVIDER: S-EPMC12613605 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature