Neurogenic inducers inhibit the proliferation of pancreatic cancer by promoting tumor cell transdifferentiation.

ABSTRACT:

Background

Tumor cell differentiation is a critical determinant of malignancy and clinical treatment selection. Pancreatic ductal adenocarcinoma (PDAC), a poorly differentiated and highly aggressive tumor, has a poor prognosis, whereas well-differentiated tumors often correlate with better outcomes. The mechanisms underlying differentiation and its therapeutic potential remain unclear.

Objectives

This study aims to investigate whether inducing transdifferentiation in pancreatic cancer cells can reduce malignancy, focusing on the role of the transcription factor NeuroD1 and its regulatory pathways.

Methods

We analyzed single-cell RNA-seq data from the GEO database to identify differentiation-associated genes. NeuroD1 was overexpressed in PDAC cells to assess its effect

SUBMITTER: Guo D 

PROVIDER: S-EPMC12613626 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature