Vitamin D elicits tissue-specific isoform expression in Atlantic salmon muscles.

ABSTRACT:

Background

Accounting for isoforms is likely key to understanding muscle transcriptomic divergence. Muscles offer classic examples of tissues where changes in isoforms alter function and structure in response to stimuli like increased exercise or novel nutrient regimes. To determine how an essential micronutrient alters muscle isoform production, we examined how vitamin D supplementation influences transcription at multiple hierarchical levels across four Atlantic salmon (Salmo salar) muscle tissues. Specifically, we investigated whether analyses of differential transcript expression (DTE), differential transcript usage (DTU), and alternative splicing (DAS) recovered different responses to vitamin D compared to differential gene expression (DGE) alone.

Results

Vitamin D modu

SUBMITTER: Gorman CE 

PROVIDER: S-EPMC12613645 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature