Efficacy of radioactive iodine therapy with concomitant antithyroid drugs in Japanese patients with Graves' disease: a retrospective observational study.

ABSTRACT:

Objective

Radioactive iodine therapy (RIT) for Graves' disease (GD) often involves antithyroid drugs (ATDs) withdrawal and the exacerbation of thyrotoxicosis. This study investigated the efficacy of RIT with concomitant ATDs (CATD) versus temporary ATDs withdrawal in Japanese patients with GD, a population with high iodine intake according to global standards.

Results

This retrospective observational study included 179 patients with GD who visited the University of Tsukuba Hospital. Propensity score matching (balancing age, sex, thyroid weight, free T4) created comparable groups of 15 patients each: CATD(-) withdrawing ATDs and CATD(+) continuing ATDs during RIT. Cure was defined as hypothyroidism or euthyroidism achieved without ATDs or potassium iodide. Post-matching, the

SUBMITTER: Osaki Y 

PROVIDER: S-EPMC12613672 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature