TNF-α inhibitor etanercept improves cerebrovascular function in elderly RA patients: findings from a randomized controlled trial.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease that can affect the cardiovascular and cerebrovascular systems. Elderly RA patients face a significantly elevated risk of cerebrovascular events, the core mechanism of which may be related to chronic inflammation-mediated vascular endothelial dysfunction and impaired cerebral blood flow regulation. Tumor necrosis factor-alpha (TNF-α) is a key pro-inflammatory cytokine in RA, yet whether its inhibitor can improve cerebral hemodynamics remains unclear. This study aims to investigate the effects and underlying mechanisms of TNF-α inhibitor etanercept on cerebral blood flow in elderly RA patients.

Objective

This study aimed to evaluate the effects of the TNF-α inhibitor Etanercept on cerebral hemo

SUBMITTER: Ren QQ 

PROVIDER: S-EPMC12613686 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature