3D printing of acetaminophen suppository and its quality and pharmacokinetic evaluation.

ABSTRACT:

Introduction

Acetaminophen is a widely used antipyretic and analgesic treatment. Becuase oral administration poses a risk of acute liver failure, researchers are exploring alternative routes of administration using 3D printing.

Methods

This study reports a novel 3D-printed suppository using hot melt extrusion and melt deposition molding technologies. Through excipients screening, process screening and 3D printing, the production can be filtered to the most optimal state. After successfully prepared 3D printed acetaminophen suppository, the suppository's performance and pharmacokinetics profile were also evaluated.

Results

Prepared 3D printed suppository has a complete appearance, smooth interlayer stacking and qualified content determination with over 90% within 6 hou

SUBMITTER: Chen M 

PROVIDER: S-EPMC12613722 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature