The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs.

ABSTRACT:

Background

A phenotype characterized by age-dependent hairless, thicker and systemic wrinkled skin has been discovered from Chinese native Xiang pig herd, which is similar to the wrinkle skin phenotype and hereditary periodic fever syndrome observed in Shar-Pei dog. Our aim was to elucidate the functional mechanisms associated with these systemic wrinkle phenotype.

Results

Gene expression changes in wrinkled skin were first explored via RNA-seq technology. There were 699 differentially expressed genes (DEGs) in wrinkled skin, with 272 downregulated genes and 427 upregulated genes. Most of the upregulated genes were significantly centered at pathways that generate reactive oxygen species (ROS), such as carbon and lipid metabolism, the citrate cycle and the oxidation-reduction

SUBMITTER: Hu F 

PROVIDER: S-EPMC12613727 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature