Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration.

ABSTRACT:

Background

Determining whether MRI brain scans demonstrate atrophy that is beyond "normal for age" is challenging. Automated measurements of structural metrics in individual brain regions have shown promise as biomarkers of neurodegeneration, yet widely available reference standards that aid interpretation at the individual level are lacking. Normative modelling, enabling standardized "brain charts", represents a significant step in addressing this challenge by generating individualized age- and sex- adjusted centile scores derived from large, aggregated datasets for MRI-derived quantitative metrics.

Methods

Using normative data from 56,173 participants across the life course, we have developed regional cortical thickness and amygdala/hippocampal volume brain charts (adjuste

SUBMITTER: Parker TD 

PROVIDER: S-EPMC12613731 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature