Neoadjuvant chemotherapy followed by surgery versus upfront surgery for intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Whether neoadjuvant chemotherapy (NAT) is beneficial for resectable and locally advanced intrahepatic cholangiocarcinoma (ICC) is still controversial. This study aimed to compare the efficacy of NAT followed by surgery and upfront surgery for ICC treatment.

Method

Embase, Pubmed, Web of Science and Cochrane library databases were searched to obtain comparative studies. The non-randomized interventions (ROBINS-I) was used to assess the methodological quality of included studies. The primary outcomes included 1-year, 3-year and 5-year overall survival (OS). The secondary outcomes were R0 resection, 1-year and 3-year recurrence-free survival (RFS).

Results

Nine retrospective studies were included in the meta-analysis. A total of 8211 patients were included in

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12613760 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature