Retinal ALKBH5 inhibition induces myopia protection through selective regulation of ERK1/2 signaling.

ABSTRACT:

Background

Myopia has reached epidemic proportions globally with limited therapeutic targets. This study elucidated the pivotal role of retinal epitranscriptomic regulation in myopia pathogenesis, aiming to identify novel therapeutic targets for myopia control.

Methods

The study enrolled 38 myopic patients scheduled for refractive surgery to analyze peripheral blood N6-methyladenosine (m6A) levels. In parallel, we established a murine form-deprivation myopia (FDM) model to examine retinal m6A dynamics and Alkylation repair homolog protein 5 (ALKBH5) expression. Pharmacological interventions using the ALKBH5 inhibitor DDO-2728 and Extracellular signal-related kinases 1 and 2 (ERK1/2) activator Ro67-7476 were administered intravitreally. To genetically validate the role of ALK

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12613781 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature