Influence of early enteral nutrition on mortality of adult patients with sepsis: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Early enteral nutrition (EEN) has been proposed to improve clinical outcomes in critically ill patients with sepsis. However, the survival benefit of EEN remains uncertain. This meta-analysis aimed to evaluate the effect of EEN on all-cause mortality in adult patients with sepsis.

Methods

A systematic search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang was conducted up to May 25, 2025. Randomized controlled trials (RCTs) comparing EEN (initiated within 24-48 h of admission or sepsis diagnosis) vs. non-early enteral nutrition (delayed enteral nutrition or parenteral nutrition) in adult septic patients were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence

SUBMITTER: Xu J 

PROVIDER: S-EPMC12613790 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature