Radiomics analysis of pericoronary adipose tissue for detecting ischaemia with non-obstructive coronary arteries in NAFLD patients.

ABSTRACT:

Background

Chronic low-grade inflammation in nonalcoholic fatty liver disease (NAFLD) plays a critical role in the development of cardiovascular complications, particularly ischaemia with non-obstructive coronary arteries (INOCA). This study aimed to develop and evaluate models combining pericoronary adipose tissue (PCAT) radiomics, PCAT attenuation (PCATa), CCTA plaque parameters, and clinical risk factors to identify INOCA in NAFLD patients.

Methods

This retrospective study included 159 patients with NAFLD who underwent CCTA. The patients were randomly divided into the training (70%) and validation (30%) cohorts. Clinical features, CCTA imaging indicators, and right coronary artery PCAT radiomic features were analyzed. Five models were constructed using logistic regression

SUBMITTER: Wang L 

PROVIDER: S-EPMC12613792 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature